Towards CMOS Capacitance Sensors for DNA Origami Characterization

M. S. R. Sajal et al., "Towards CMOS Capacitance Sensors for DNA Origami Characterization," 2023 International Electron Devices Meeting (IEDM), San Francisco, CA, USA, 2023, pp. 1-4 [Online Article]

This work features a novel capacitance biosensor for characterizing DNA origami. The biosensor was fabricated in a 0.18 μm CMOS process, and it consisted of an 8 × 8 array of passivated interdigitated electrodes where each electrode is coupled to a dedicated capacitance-to-frequency conversion circuit. We further show a self-referencing data acquisition scheme for reducing the variance in DNA origami measurements.