Tracking the Effects of Tumor Treating Fields on Human Breast Cancer Cells in vitro Using a Capacitance Sensing Lab-on-CMOS Microsystem

Y. Gilpin, C. -Y. Lin, M. Forssell, S. Zheng, P. Grover and M. Dandin, "Tracking the Effects of Tumor Treating Fields on Human Breast Cancer Cells in vitro Using a Capacitance Sensing Lab-on-CMOS Microsystem," 2022 29th IEEE International Conference on Electronics, Circuits and Systems (ICECS), Glasgow, United Kingdom, 2022, pp. 1-4 [Online Article]

We report on a novel microsystem for assessing the effects of tumor treating fields on cancer cells. The platform features at its core an integrated capacitance sensor fabricated in a 0.35μm CMOS process. The device also includes a cell culture well and miniaturized electrodes for generating arbitrary TTField spatial patterns. The measured capacitance data show a clear distinction between cell cultures treated with TTFields relative to those that remain unexposed. The proposed approach provides an inexpensive, real-time, and label-free means to conduct mechanistic TTField studies in vitro.